The story focuses around the lives of two best friends, who fall in love with each other, Ranveer Vaghela and Ishaani Parekh.
Both of the friends have to face several difficulties in reuniting, particularly by Chirag Mehta, Ritika Zaveri, Milan Vaghela and Nirbhay Singh Ahlawat. However, any difficulties do not weaken their love.
Standing side by side, Ranveer and Ishaani are forced to give up their love everytime troubles knock at the door-step. But Ranveer and Ishaani's love is very strong. Therefore, each time they both realize their love for one another.
This is the concept of Meri Aashiqui Tum Se Hi that is also abbreviated as MATSH.